Comment: Barbiturates may possibly raise adverse effects, which include respiratory depression, produced by harmful doses of TCAs. With therapeutic doses of TCAs, barbiturates increase metabolism and decrease blood concentrations of TCAs. pentobarbital will lessen the extent or outcome of disopyramide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Slight/Significance Unknow... https://charlesu777iar8.answerblogs.com/profile