Here, we display that conolidine, a pure analgesic alkaloid used in conventional Chinese medication, targets ACKR3, thus supplying additional proof of the correlation involving ACKR3 and discomfort modulation and opening different therapeutic avenues with the treatment of Continual soreness. The first asymmetric complete synthesis of conolidine was produced by https://scottm617vcg0.azuria-wiki.com/user