Epidural clonidine employed as an adjunct to regional anesthetics has three various mechanisms of action. To start with, the stimulation of alpha-2-receptors during the dorsal horn decreases pain transmission. Next, clonidine may cause regional vasoconstriction that limits vascular elimination of nearby epidural anesthetics. Among the theories with regard to https://www.proleviate.com/post/the-new-pain-killer-conolidine