Conolidine’s analgesic results stem from its interaction with non-opioid pain pathways. In contrast to opioids, which bind to µ-opioid receptors within the central anxious method, conolidine modulates alternate molecular targets. A Science Developments study identified that conolidine interacts with the atypical chemokine receptor ACKR3/CXCR7, which regulates opioid peptide availability. https://whyshouldiuseconolidine00886.alltdesign.com/alternative-natural-pain-relief-to-replace-traditional-painkillers-options-56719172