Investigation into conolidine has brought about discovery of an opioid receptor in the body known as ACKR3/CXCR7. ACKR3 seems to be the most popular target for conolidine, which also disregards another four classical opioid receptors(three). **This is a subjective assessment depending on the strength in the available informations and https://socialbuzzfeed.com/story6367431/not-known-details-about-conoldine-alternative-natural-pain-relief